Lung mitochondria in experimental asbestosis
作者： Ballabh Das , Virendra Misra , P.N. Viswanathan , Qamar Rahman
DOI: 10.1016/0013-9351(83)90017-8
关键词: Cytochrome c oxidase 、 Chrysotile 、 Biochemistry 、 Internal medicine 、 Lung 、 Monoamine oxidase 、 Asbestosis 、 Glycosaminoglycan 、 Enzyme 、 Mitochondrion 、 Biology 、 Endocrinology
摘要: Alterations in lung mitochondria were followed guinea pigs at different periods after a single intratracheal injection of chrysotile dust. Cytochrome c oxidase and succinic dehydrogenase activities showed gradual increase 90 days, whereas monoamine remained unaffected throughout the study. There was an glutamate activity postmitochondrial as well mitochondrial fractions, latter being accompanied by decreased latency enzyme. Mitochondria from asbestotic appeared to be more swollen than normal animals days exposure. fluctuations contents phospholipids result asbestosis. Beyond collagen mucopolysaccharides also increased. The results confirm contention that pulmonary are among major target sites
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