VP 16-213 in acute myelogenous leukaemia.

摘要: The use of the epipodophyllotoxin VP 16-213 is described in twenty patients with acute myelogenous leukaemia resistant to other chemotherapy. drug was usually given 5-day courses 50 mg/m 2 daily and occasionally 24-hr infusions 250 , on basis its phase-activity. Complete remission achieved only two patients: one these, maintained for 8 months, 10 weeks. A partial response patient. Seventeen showed no response. No responses or remissions were when used a infusion. Side effects minimal, degree marrow depression much less than most agents known be active leukaemia. It interest that patient without customary period hypoplasia. suggested that, although appears have minimal activity dosage here, improvement might sought by increasing dosage, scheduling different way, using it combination chemotherapy regime.