Pseudoconservative transition: A two-state model for the co-operative behavior of oligomeric proteins

作者: Odile M. Viratelle , François J. Seydoux

DOI: 10.1016/0022-2836(75)90223-5

关键词: Diagnostic testLigand (biochemistry)State modelChemical physicsAsymmetryCo operativeStereochemistryChemistryBinding propertiesMolecular biology

摘要: Abstract A plausible extension of the two-state concerted model is proposed. This extended involves at least one state with pairwise asymmetry and consequent heterogeneous binding properties. Such a pseudoconservative transition accounts in predictably restricted manner for either positive or negative co-operativity † combination both single ligand. State saturation functions are derived. Variation Hill number respect to extent provides diagnostic test co-operativities ligand binding. Applications recent experimental data discussed.

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