Accessory cell signals regulate Th-cell responses: from basic immunology to a model of helminthic disease
作者： Miguel J. Stadecker , Pedro O. Flores Villanueva
DOI: 10.1016/0167-5699(94)90219-4
关键词: Downregulation and upregulation 、 Antigen-presenting cell 、 Interleukin 10 、 Cell 、 Granuloma 、 Lymphocyte 、 Immunology 、 Disease 、 Biology 、 Helminthiasis
摘要: Schistosome helminths inflict serious tissue damage by eliciting T helper (Th)-cell-mediated granulomatous inflammation around parasite eggs. The egg granulomas are large in acute disease and smaller chronic disease. To explain this downregulation disease, Miguel Stadecker Pedro Flores Villanueva describe a mechanism whereby CD4+ Th1-type lymphocytes, which associated with the initial vigorous granuloma formation, rendered anergic to subsequent antigenic stimulation. This results reduction of size dominance Th2-type lymphocyte responses.
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