APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease
作者： Yen Ying Lim , Victor L Villemagne , Robert H Pietrzak , David Ames , Kathryn A Ellis
DOI: 10.1016/J.NEUROBIOLAGING.2014.12.008
关键词: Apolipoprotein E 、 Episodic memory 、 Cognitive decline 、 Mini–Mental State Examination 、 Psychology 、 Internal medicine 、 Gerontology 、 Clinical Dementia Rating 、 Oncology 、 Disease 、 Cognition 、 Alzheimer's disease
摘要: Abstract The apolipoprotein E ( APOE ) ɛ4 allele and high levels of beta-amyloid (Aβ) are associated with episodic memory decline risk for Alzheimer's disease. However, there is debate about independent or interactive effects on Aβ-related in healthy older adults. Healthy adults Aβ burden (n = 84) enrolled Australian Imaging, Biomarkers, Lifestyle Study were included this study. Cognition was measured using the computerized Cogstate Brief Battery at baseline, 18-, 36-, 54-month follow-ups. Mini Mental State Examination Clinical Dementia Rating scales also administered baseline each follow-up timepoint. Relative to Aβ+ noncarriers 36), carriers 48) showed significantly faster tasks, which by convention, moderate magnitude d = 0.40–0.47). positivity coupled moderately increased over a assessment period, suggesting that, preclinical stages disease, manifestation exacerbated presence ɛ4.
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Francisco J de Abajo, Luis A García Rodríguez, Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations BMC Clinical Pharmacology. ,vol. 1, pp. 1- 8 ,(2001) , 10.1186/1472-6904-1-1
Yen Ying Lim, , Kathryn A. Ellis, Karra Harrington, Adrian Kamer, Robert H. Pietrzak, Ashley I. Bush, David Darby, Ralph N. Martins, Colin L. Masters, Christopher C. Rowe, Greg Savage, Cassandra Szoeke, Victor L. Villemagne, David Ames, Paul Maruff, Cognitive Consequences of High Aβ Amyloid in Mild Cognitive Impairment and Healthy Older Adults: Implications for Early Detection of Alzheimer's Disease Neuropsychology (journal). ,vol. 27, pp. 322- 332 ,(2013) , 10.1037/A0032321
Qingguang Jiang, CY Daniel Lee, Shweta Mandrekar, Brandy Wilkinson, Paige Cramer, Noam Zelcer, Karen Mann, Bruce Lamb, Timothy M Willson, Jon L Collins, Jill C Richardson, Jonathan D Smith, Thomas A Comery, David Riddell, David M Holtzman, Peter Tontonoz, Gary E Landreth, None, ApoE Promotes the Proteolytic Degradation of Aβ Neuron. ,vol. 58, pp. 681- 693 ,(2008) , 10.1016/J.NEURON.2008.04.010
K. Kantarci, V. Lowe, S. A. Przybelski, S. D. Weigand, M. L. Senjem, R. J. Ivnik, G. M. Preboske, R. Roberts, Y. E. Geda, B. F. Boeve, D. S. Knopman, R. C. Petersen, C. R. Jack, APOE modifies the association between Aβ load and cognition in cognitively normal older adults Neurology. ,vol. 78, pp. 232- 240 ,(2012) , 10.1212/WNL.0B013E31824365AB
Jesus J Gomar, Concepcion Conejero-Goldberg, Peter Davies, Terry E Goldberg, Alzheimer's Disease Neuroimaging Initiative, Extension and refinement of the predictive value of different classes of markers in ADNI: Four‐year follow‐up data Alzheimers & Dementia. ,vol. 10, pp. 704- 712 ,(2014) , 10.1016/J.JALZ.2013.11.009
Robert G. Newcombe, Confidence intervals for an effect size measure based on the Mann-Whitney statistic. Part 1: general issues and tail-area-based methods. Statistics in Medicine. ,vol. 25, pp. 543- 557 ,(2006) , 10.1002/SIM.2323
Richard J. Caselli, Dona E.C. Locke, Amylou C. Dueck, David S. Knopman, Bryan K. Woodruff, Charlene Hoffman-Snyder, Rosa Rademakers, Adam S. Fleisher, Eric M. Reiman, The neuropsychology of normal aging and preclinical Alzheimer's disease Alzheimers & Dementia. ,vol. 10, pp. 84- 92 ,(2014) , 10.1016/J.JALZ.2013.01.004
Christopher C. Rowe, Pierrick Bourgeat, Kathryn A. Ellis, Belinda Brown, Yen Ying Lim, Rachel Mulligan, Gareth Jones, Paul Maruff, Michael Woodward, Roger Price, Peter Robins, Henri Tochon‐Danguy, Graeme O'Keefe, Kerryn E. Pike, Paul Yates, Cassandra Szoeke, Olivier Salvado, S. Lance Macaulay, Timothy O'Meara, Richard Head, Lynne Cobiac, Greg Savage, Ralph Martins, Colin L. Masters, David Ames, Victor L. Villemagne, Predicting Alzheimer disease with β-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing Annals of Neurology. ,vol. 74, pp. 905- 913 ,(2013) , 10.1002/ANA.24040
Yen Ying Lim, Kathryn A Ellis, Robert H Pietrzak, David Ames, David Darby, Karra Harrington, Ralph N Martins, Colin L Masters, Christopher Rowe, Greg Savage, Cassandra Szoeke, Victor L Villemagne, Paul Maruff, AIBL Research Group, Alan Rembach, Alex Bahar-Fuchs, Andrew Milner, Ashley Bush, Belinda Brown, Bill Wilson, Brett Trounson, Christopher O'Halloran, Darshan Trivedi, Fiona Lamb, Gael Chetelat, Gareth Jones, Graeme O'Keefe, James Lui, Jo Robertson, Jurgen Fripp, Kelly Pertile, Maree Farrow, Michael Woodward, Miroslava Rimajova, Neil Killeen, Nicola Lautenschlager, Noel Faux, Olga Yastrubetskaya, Olivier Salvado, Parnesh Raniga, Paul Yates, Pierrick Bourgeat, Qiao-Xin Li, Rebecca Lachovitski, Rebecca Rumble, Roger Clarnette, Simon Laws, Simon McBride, Tania Taddei, Tiffany Cowie, Vanessa Ward, Vincent Dore, Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults Neurology. ,vol. 79, pp. 1645- 1652 ,(2012) , 10.1212/WNL.0B013E31826E9AE6
D. S. Knopman, β-Amyloidosis and neurodegeneration in Alzheimer disease: who's on first? Neurology. ,vol. 82, pp. 1756- 1757 ,(2014) , 10.1212/WNL.0000000000000438