Amyloid-Related Memory Decline in Preclinical Alzheimer's Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.
作者： Christine Thai , Yen Ying Lim , Victor L Villemagne , Simon M Laws , David Ames
DOI: 10.1371/JOURNAL.PONE.0139082
关键词: Cognitive decline 、 Internal medicine 、 Effects of sleep deprivation on cognitive performance 、 California Verbal Learning Test 、 Verbal memory 、 Endocrinology 、 Medicine 、 Gerontology 、 Alzheimer's disease 、 Memory disorder 、 Episodic memory 、 Apolipoprotein E
摘要: High levels of β-amyloid (Aβ) in the brain and carriage APOE e4 allele have each been linked to cognitive impairment cognitively normal (CN) older adults. However, relationship between these two biomarkers decline is unclear. The aim this study was investigate cerebral Aβ level, carrier status, over 18 months, 317 healthy adults (47.6% males, 52.4% females) aged 60 89 years (Mean = 69.9, SD 6.8). Cognition assessed using Cogstate Brief Battery (CBB) California Verbal Learning Test, Second Edition (CVLT-II). Planned comparisons indicated that CN with high who were also carriers demonstrated most pronounced learning working memory. In non-carriers, unrelated Carriage low associated a significantly increased rate unexpectedly, improved performance on measures verbal episodic memory months. These results suggest interact increase provide further support for use as early Alzheimer’s disease.
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