Urinary iodine excretion and thyroid function status in school age children of hilly and plain regions of Eastern Nepal

摘要: Iodine deficiency is a major public health problem in many developing countries including Nepal. The present study was designed to investigate the urinary iodine excretion (UIE), thyroid function status and household salt content (SIC) school-aged children (SAC) establish relationships between these factors. A community-based cross sectional conducted selected schools of two districts, Tehrathum Morang, lying hill plain region eastern Nepal respectively. total 640 SAC, (Tehrathum n = 274 Morang n = 366) aged 6–11 years, were assessed for UIE SIC. Among children, 155 consented blood samples n = 78 n = 77) test serum thyroglobulin (Tg), stimulating hormone (TSH), free triiodothyronine (fT3) thyroxine (fT4). measured by ammonium persulfate digestion method. SIC iodometric titration method Tg, TSH, fT4 fT3 immunoassay based kit In 9.5 7.7 % SAC had values 299 µg/L, with median 345.65 270.36 µg/L overall medians as follows, Tg 14.29 µg/L, 3.94 pmol/L, 16.25 pmol/L TSH 3.61 mIU/L. There negative correlation (r = −0.236, p = 0.003) positive (r = 0.349, p < 0.0001). We found 19.5 %, n = 15 16.7 %, n = 13 subclinical hypothyroid cases Iodometric showed only 6.4% (n = 41) <15 ppm. Multivariate analysis revealed that use packaged district correlated higher values. Our focused data suggests collaborative universal iodization (USI) programs are improving districts also excessive large portion groups substantial concern intervention need deal both deficient scenarios can be simultaneously populations.