Estimating the Burden of Pneumococcal Pneumonia among Adults: A Systematic Review and Meta-Analysis of Diagnostic Techniques

作者: Maria A. Said , Hope L. Johnson , Bareng A. S. Nonyane , Maria Deloria-Knoll , Katherine L. O′Brien

DOI: 10.1371/JOURNAL.PONE.0060273

关键词: Intensive care medicineStreptococcus pneumoniaePneumoniaSputumMeta-analysisPneumococcal pneumoniaBacteremiaMedicineIncidence (epidemiology)Disease burden

摘要: Background Pneumococcal pneumonia causes significant morbidity and mortality among adults. Given limitations of diagnostic tests for non-bacteremic pneumococcal pneumonia, most studies report the incidence bacteremic or invasive disease (IPD), thus, grossly underestimate burden. We aimed to develop a conceptual quantitative strategy estimate burden adults with community-acquired (CAP) using systematic study methods availability urine antigen assay.

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