Embryonic stem cell transplantation: potential applicability in cell replacement therapy and regenerative medicine

摘要: Embryonic stem cells are derived from the inner cell mass of trophoblast, and have ability to differentiate into all tissues fetus. As such, their potential in replacement therapy regenerative medicine has been widely acknowledged. Useful types such as neurons, cardiomyocytes, hepatocytes, pancreatic beta cells, blood successfully laboratory. Furthermore, embryonic may be utilized novel immunomodulatory applications, hematopoietic chimerism strategies aimed at inducing tolerance donor organ allografts. Unfortunately, progress therapeutics continues hindered by haphazard differentiation tumorigenesis; immune response an cell-derived tissue graft is still open question. This review summarizes current state research regards transplantation, highlighting successes date future obstacles yet overcome. Although far debut clinic, continued scientific advances engender optimism that they will eventually play important role medicine.