Regulation of Fatty Acid Biosynthesis

摘要: Publisher Summary The de novo synthesis of saturated fatty acids, studied in a variety biological systems, is catalyzed by two enzyme acetyl-CoA carboxylase and acid synthetase. These complexes are found the cell cytoplasm when cells ruptured cellular components fractionated usual techniques. All carbon atoms acids derived from acetyl-CoA. Although palmitate major that produced most biosynthetic chain length varies different sources under experimental conditions. Examination substrates synthesis, acetyl-CoA, adenosine triphosphate (ATP), nicotinamide adenine dinucleotide phosphate-oxidase (NADPH), suggests this pathway can be controlled regulation availability these substrates. Acetyl-CoA catalyzes first reaction which unique to pathway, and, therefore, regulated.