Burkitt-like lymphomas in AIDS patients: characterization within a series of 103 human immunodeficiency virus-associated non-Hodgkin's lymphomas. Burkitt's Lymphoma Study Group.

摘要: PURPOSEBurkitt-like lymphoma (BLL) is a tumor with morphologic features intermediate between Burkitt's (BL) and large-cell lymphoma, but its relationship these lymphomas currently unclear. We have therefore analyzed characteristics within large series of human immunodeficiency virus (HIV)-associated lymphomas.MATERIALS AND METHODSClinical, histologic, immunophenotypic, molecular analyses were performed on 103 patients AIDS lymphomas.RESULTSNineteen cases (18.4%) identified as BLL. They monoclonal B-cell proliferations, evaluated by immunoglobulin (Ig) gene rearrangement analyses, had the c-myc oncogene in 68% not bcl-2 gene, contrast to previous study non-HIV-associated This pattern was identical that typical BL, suggesting they represented tumors similar origin. However, some could clearly differentiate BLL from BL those seen diffuse large-c...