Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription
作者： Fabienne Brégeon , Antoine Roch , Stéphane Delpierre , Eric Ghigo , Amapola Autillo-Touati
DOI: 10.1016/S1569-9048(02)00069-1
关键词: Positive end-expiratory pressure 、 Tidal volume 、 Oxygenation 、 Internal medicine 、 Respiratory system 、 Endocrinology 、 Arterial blood 、 Lung 、 Mechanical ventilation 、 Pathology 、 Bronchoalveolar lavage 、 Medicine 、 Physiology 、 General Neuroscience 、 Pulmonary and Respiratory Medicine
摘要: We investigated the potential inflammatory reaction induced by mechanical ventilation (MV) using 10 ml/kg tidal volume and no positive end-expiratory pressure (PEEP) in control (C, n = 8), spontaneously breathing (SB, 12) mechanically ventilated (MV, rabbits with normal lungs. After 6 h (MV SB groups) or immediately (C group), lungs were removed for measurement of wet-to-dry (W/D) weight ratio bronchoalveolar lavage (BAL). Pulmonary mechanics also studied. MV animals developed a modest but significant (P < 0.01) impairment arterial blood oxygenation had higher W/D lung than C ones. In group, BAL macrophage count was greater 0.05) one. an upregulation MCP-1, TNF-alpha, IL-1beta gene transcription (mRNAs), without elevation corresponding protein cytokines supernatant, except MCP-1 0.05). These data suggest that MV, even moderate volume, elicits pro-inflammatory stimulus to
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