作者: Douglas C. Wallace
DOI: 10.1146/ANNUREV.BIOCHEM.76.081205.150955
关键词: DNA 、 Inner mitochondrial membrane 、 Mitochondrial disease 、 Mitochondrial DNA 、 Oxidative phosphorylation 、 Genetics 、 Gene 、 Biology 、 Human mitochondrial genetics 、 Mitochondrion
摘要: … Because the mtDNA genes are all essential for oxidative phosphorylation (OXPHOS) and thus critical for life and health, the high mtDNA mutation rate means that diseases of the …