Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine

作者: Douglas C. Wallace

DOI: 10.1146/ANNUREV.BIOCHEM.76.081205.150955

关键词: DNAInner mitochondrial membraneMitochondrial diseaseMitochondrial DNAOxidative phosphorylationGeneticsGeneBiologyHuman mitochondrial geneticsMitochondrion

摘要: … Because the mtDNA genes are all essential for oxidative phosphorylation (OXPHOS) and thus critical for life and health, the high mtDNA mutation rate means that diseases of the …

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