Mannosylated solid lipid nanoparticles for lung-targeted delivery of Paclitaxel.
作者： Piyush Kumar Sahu , Deepak Kumar Mishra , Nivrati Jain , Vaibhav Rajoriya , Ashish Kumar Jain
DOI: 10.3109/03639045.2014.891130
关键词: Chemistry 、 Paclitaxel 、 Biochemistry 、 Zeta potential 、 Mannosylation 、 Biophysics 、 A549 cell 、 Cytotoxicity 、 Conjugate 、 Mannose 、 Solid lipid nanoparticle
摘要: AbstractObjective: The present study discusses paclitaxel (PTX)-loaded mannosylated-DSPE (Distearoyl-phosphatidyl-ethanolamine) solid lipid nanoparticles (M-SLNs) using mannose as a lectin receptor ligand conjugate for lung cancer targeting and to increase the anticancer activity of PTX against A549 lung’s epithelial cells.Materials methods: PTX-SLNs were prepared by solvent injection method was conjugated free amine group stearylamine. M-SLNs obtained characterized their particle size, polydispersity index, zeta potential morphology transmission electron microscope.Results: spherical in shape with 254 ± 2.3 nm average positive (3.27 mV), 79.4 ± 1.6 drug entrapment efficiency showed lower extent release 40% over 48 h vitro. Cytotoxicity on cell lines biodistrubtion revealed that deliver higher concentration compared an alveolar cell...
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