Enhanced tumor necrosis factor-α production following endotoxin challenge in rats is an early event during magnesium deficiency

摘要: Abstract Magnesium (Mg) plays an essential role in fundamental cellular reactions and the importance of immuno-inflammatory processes pathology Mg deficiency has been recently reconsidered. The purpose present study was to assess effect different stages on endotoxin response tumor necrosis factor-α (TNFα) production. Weaning male Wistar rats were pair fed either a Mg-deficient or control diet. At day 7, lipopolysaccharide (LPS) induced no lethal effects but resulted 70% mortality within 3 h. vulnerability LPS associated with higher TNFα plasma values. animals that received magnesium supplementation before challenge had significantly increased survival. 2, also subjected without pre-treatment. A significant increase level observed compared replacement therapy lower values than those receiving saline endotoxin. Thus, results this experiment suggest activated primed state immune cells is early event occurring deficiency.