Dynamics of Extracellular Calcium Activity Following Contusion of the Rat Spinal Cord
作者： T. MORIYA , A.Z. HASSAN , W. YOUNG , M. CHESLER
关键词: Pathophysiology 、 Total Tissue 、 Central nervous system disease 、 Extracellular 、 Calcium 、 Spinal cord 、 Anatomy 、 Spinal cord surface 、 Context (language use) 、 Medicine
摘要: ABSTRACT The role of Ca2+ in cellular injury has received particular attention studies acute spinal cord trauma. In this context, the spatial and temporal distribution extracellular ([Ca2+]e) may have an important bearing on development secondary tissue injury. We therefore studied spatial–temporal [Ca2+]e following moderate (25 g-cm) contusive to rat thoracic (T9–T11) cord. Double-barreled, Ca2+-selective microelectrodes were used measure magnitude time course at increasing depths from dorsal surface. After 2 h, was frozen later analyzed for total Ca concentration using atomic absorption spectroscopy. fell all depths, but decrease maximal 250 500 μm surface, where, 0–10 min after injury, averaged 0.09 ± 0.03 0.06 mM respectively. By h postinjury, recovered nearly 1 across depths. Over time, cal...
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