Regenerative Therapy for Spinal Cord Injury

摘要: The ability of the adult CNS to recover from injury is highly limited. To date, spinal cord and brain lesions have been seen as irreversible. However, remarkable achievements last 30 years reversed profound pessimism that once surrounded issue repair. There now a rapid expansion in this field neuroscience. Studies animal models increased our knowledge cellular molecular aspects neurite growth, guidance, target finding synapse stabilisation. Investigations laboratory animals shown lesioned axons are able elongate over large distances when treated with antibodies against growth inhibitors, or trophic factors substrates stimulate growth. These results well established first indications functional recovery resulting such treatments published. Experimental clinical studies neuroprotective treatment sparing secondary possible. Forthcoming multicentre trials treatment, started early after injury, can partially restore neurological function. Such set standards for current patients injury. This article briefly reviews recent preclinical developments regenerative therapies repair injured cord.