Neuropeptides and anxiety-related behavior

摘要: Behavior is shaped by a variety of genetic and epigenetic mechanisms, including those underlying anxiety fear. Neuropeptides are ideal candidates to be involved in the regulation emotional facets as they released within brain act neuromodulators/neurotransmitters; furthermore, their large number prone direct changes mutations. A approaches have been used reveal physiological involvement neuropeptides anxiety-related behavior, focused on behavioral effects and, vice versa, influence phenomena intracerebral neuropeptides. In concert with other classical transmitters, particularly CRH vasopressin promising candidate determine not only activity hypothalamo-pituitary-adrenocortical axis, but also behavior its cognitive components. interactions specific receptor subtypes shown induce consequences emotionality, responses both anxiogenic stimuli extreme levels inborn confirm critical normal pathological anxiety. Based neuroendocrine data obtained from proper animal models, neurobiological analyses fear will provide prerequisites develop novel more causal therapeutic strategies for disorders.