Effects of footshocks on anxiety-like behavior and mRNA levels of precursor peptides for corticotropin releasing factor and opioids in the forebrain of the rat.
作者： Huiying Wang , Sa Li , Gilbert J. Kirouac
DOI: 10.1016/J.NPEP.2015.08.010
关键词:
摘要: Corticotropin releasing factor (CRF) and dynorphin are neuropeptides that associated with the negative emotional states. Experimental evidence indicates neurons located in nucleus accumbens CRF bed of stria terminalis (BST) central amygdala (CeA) mediate anxiety-like behaviors immediately after stressful experience (24-48h). The present study was done to evaluate if changes levels mRNA for these peptides striatum, BST, CeA were long-lasting avoidance novelty, a measure an state, subset rats exposed unpredictable moderately intense footshocks (5×2s 1.5mA). Shocked enhanced fear novel tone 24h (high responders; HR) displayed elevated T-maze whereas shocked low acute (low LR) had similar nonshocked rats. An increase level proCRF detected HR compared LR but not other areas brain sampled. In contrast, prodynorphin proenkephalin BST different between HR, This provides may play role state produced footshocks.
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