Central side effects of pentamethylmelamine: Biochemical and behavioural studies

摘要: Abstract The central side effects of pentamethylmelamine (PMM), an antitumoral agent, were studied on brain neurotransmitters from the biochemical and behavioural points view. PMM causes a dose-related reduction in body temperature motility mice. 100 mg/kg lowers levels noradrenaline (NA) raises 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) telencephalon. A similar dose increased striatal dopamine (DA) metabolites, homovanillic acid (HVA) dihydroxyphenylacetic (DOPAC), at earlier times (30 min), reducing their 2 hr. These disappear longer (4 hr). No changes observed 3-methoxytyramine (3-MT), extraneuronal metabolite DA. serotonin 5-hydroxyindolacetic (5HIAA) was almost not affected. its metabolites do displace [ 3 H]-spiroperidol mouse binding sites. data show that some neurological induced by are associated with metabolism and/or release catecholamines but mediated direct action DA receptors.