Solvation and dilution thermodynamics of benzocaine in some aqueous and organic solvents

摘要: ABSTRACTBenzocaine (BZC) is a local anaesthetic commonly used in therapeutics. Based on published thermodynamic quantities of dissolution, partitioning, and sublimation BZC, the solvation for this drug some mutually saturated solvents were calculated. Organic under consideration cyclohexane (CH), isopropyl myristate (IPM), 1-octanol (ROH). In all cases, these (i.e. , ) negative, indicating that dissolution more favourable state BZC. Thermodynamic dilution organic also Accordingly, Gibbs energies not three  > 0). From obtained values different transfer processes, an interpretation based solute–solute solute–solvent interactions was developed.