Characterization of an anionic membrane mimetic with natural phospholipid content and magnetic orienting capabilities

摘要: Abstract The cellular membrane is a highly complex and dynamical structure, with variable inhomogeneous composition, which makes detailed structural studies very difficult task. 2H-NMR has become one of the most useful tools for many such studies, however this requires use simpler structures that behave as close possible to membrane, i.e. mimetics. In article we present new anionic nematic lyotropic liquid crystal, an important content natural mixture phospholipids isolated from soybean, can be employed mimetic. capability mesophase spontaneously orient when exposed external magnetic field, enables it about distribution, dynamics mobility components, well dissolved substrates, employing 2H-NMR. A characterization mimetic performed by using different deuterated probes. To validate its permeability properties permeating Benzocaine inability Levodopa do so were tested. For atomic both, process crossing interface, also molecular simulation calibrated reproduce experimental results.