Akute lymphoblastische Leukämie (ALL) im Kindesalter
作者： Arndt Borkhardt
DOI: 10.1007/978-3-642-59343-7_11
关键词:
摘要: Die akute lymphoblastische Leukamie (ALL) ist durch die ungehemmte, klonale Proliferation unreifer lymphoider Zellen im Knochenmark gekennzeichnet. Sekundar konnen alle extramedullaren Organe, z.B. Lymphknoten, Milz, Leber, Niere, Hoden oder das zentrale Nervensystem, Blastenpopulation infiltriert werden. maligne Transformation kann auf jeder Stufe der fruhen B-oder T-Zell-Differenzierung entstehen. Dies erklart Heterogenitat ALL bzw. besonders charakterisierbaren ALL-Untertypen. Ohne zytotoxische Chemotherapie fuhrt jede obligat in wenigen Wochen infolge Knochenmarkinsuffizienz (Anamie, Thrombozytopenie, Granulozytopenie) Blutungen Infektionen zum Tod.
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sci-hub.st 参考文章(97)
Ravi Salgia, Jian-Liang Li, Darren S Ewaniuk, Warren Pear, Evan Pisick, Stephen A Burky, Timothy Ernst, Martin Sattler, Lan Bo Chen, James D Griffin, BCR/ABL induces multiple abnormalities of cytoskeletal function. Journal of Clinical Investigation. ,vol. 100, pp. 46- 57 ,(1997) , 10.1172/JCI119520
G. Götz, H. -J. Weh, T. A. Walter, R. Kuse, K. Kolbe, G. Dölken, K. P. Hellriegel, D. Hoelzer, D. K. Hossfeld, Clinical and prognostic significance of the Philadelphia chromosome in adult patients with acute lymphoblastic leukemia. Annals of Hematology. ,vol. 64, pp. 97- 100 ,(1992) , 10.1007/BF01715353
J. Michaelis, U. Kaletsch, W. Burkart, B. Grosche, Infant leukaemia after the Chernobyl accident. Nature. ,vol. 387, pp. 246- 246 ,(1997) , 10.1038/387246A0
E. Petridou, D. Trichopoulos, N. Dessypris, V. Flytzani, S. Haidas, M. Kalmanti, D. Koliouskas, H. Kosmidis, F. Piperopoulou, F. Tzortzatou, Infant leukaemia after in utero exposure to radiation from Chernobyl. Nature. ,vol. 382, pp. 352- 353 ,(1996) , 10.1038/382352A0
H. Miyoshi, K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, M. Ohki, t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 10431- 10434 ,(1991) , 10.1073/PNAS.88.23.10431
T. Caspersson, L. Zech, C. Johansson, Differential binding of alkylating fluorochromes in human chromosomes. Experimental Cell Research. ,vol. 60, pp. 315- 319 ,(1970) , 10.1016/0014-4827(70)90523-9
Wolf-Dieter Ludwig, Anand Raghavachar, Eckhard Thiel, None, 2 Immunophenotypic classification of acute lymphoblastic leukaemia Baillière's clinical haematology. ,vol. 7, pp. 235- 262 ,(1994) , 10.1016/S0950-3536(05)80201-X
G. Daley, R. Van Etten, D Baltimore, Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome Science. ,vol. 247, pp. 824- 830 ,(1990) , 10.1126/SCIENCE.2406902
M.F. Greaves, G. Brown, N.T. Rapson, T.A. Lister, Antisera to acute lymphoblastic leukemia cells Clinical Immunology and Immunopathology. ,vol. 4, pp. 67- 84 ,(1975) , 10.1016/0090-1229(75)90041-0
Tsukasa Okuda, Jan van Deursen, Scott W Hiebert, Gerard Grosveld, James R Downing, AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis Cell. ,vol. 84, pp. 321- 330 ,(1996) , 10.1016/S0092-8674(00)80986-1