Frequent epigenetic inactivation of RSK4 by promoter methylation in cancerous and non-cancerous tissues of breast cancer
作者： Qiuyun Li , Yi Jiang , Wei Wei , Yinan Ji , Hui Gao
DOI: 10.1007/S12032-013-0793-3
关键词: Regulation of gene expression 、 Carcinogenesis 、 Breast cancer 、 DNA methylation 、 Bisulfite sequencing 、 Internal medicine 、 Oncology 、 Methylation 、 CpG site 、 Epigenetics 、 Medicine 、 Cancer research 、 Hematology 、 General Medicine
摘要: Breast cancer is one of the most common cancers and second leading cause cancer-related death in women worldwide. Ribosomal s6 kinase4 (RSK4) a potential tumor suppressor multiple cancers, while its role breast largely unknown. Our study here aimed to explore relationship between RSK4 expression with clinicopathologic characteristics promoter methylation status RSK4. Real-time PCR bisulfite sequencing were, respectively, used detect difference mRNA 49 paired non-cancerous samples. The associations were analyzed. In patients' specimens, was found be significantly decreased tissues compared (p = 0.002), which due hypermethylation 0.005). Frequency higher than 0.009); not associated all clinicopathological features. silencing frequent event cancer. majority have level when tissues. may valuable biomarker for carcinogenesis progression.
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