Transcranial direct current stimulation in treatment-resistant obsessive-compulsive disorder: An open-label pilot study.

摘要: Abstract Background Obsessive–compulsive disorder (OCD) is a severe mental illness. OCD symptoms are often resistant to available treatments. Abnormalities within the orbitofronto-striato-pallido-thalamic circuitry, especially orbitofrontal cortex (OFC) hyperactivity and cerebellar hypoactivity have been observed in patients. Non-invasive brain stimulation studies indicated that transcranial direct current (tDCS) may be useful alternative alleviate treatment-resistant various neuropsychiatric conditions. Methods In an open-label pilot study, 8 patients with received 10 sessions (twice day) of 2 mA tDCS applied cathode over left OFC anode right cerebellum. (Y-BOCS OCD-VAS) as well depressive (MADRS) were measured 4 times: one time before 3 times after (immediately after, 1 3 months 10th session). Results We reported significant 26.4% (± 15.8) decrease Y-BOCS score (p = 0.002). The beneficial effect lasted during 3 month follow-up. No was on symptoms. At end point, 5 out had ≥ 25%; ≥ 35% score. tolerated. Conclusion placed combined cerebellum suitable safe approach OCD. Large scale randomized controlled needed confirm this promising result.