Progression of O6-methylguanine-DNA methyltransferase and temozolomide resistance in cancer research
作者： Guan Jiang , Ai-Jun Jiang , Yong Xin , Lian-Tao Li , Qian Cheng
DOI: 10.1007/S11033-014-3549-Z
关键词: Cancer 、 DNA methyltransferase 、 Temozolomide 、 Methylation 、 Methyltransferase 、 Cancer research 、 Mgmt expression 、 Medicine 、 Chemotherapy 、 O6-methylguanine 、 Genetics 、 Molecular biology 、 General Medicine
摘要: Temozolomide (TMZ) is an alkylating agent that widely used in chemotherapy for cancer. A key mechanism of resistance to TMZ the overexpression O6-methylguanine-DNA methyltransferase (MGMT). MGMT specifically repairs DNA O6-methylation damage induced by and irreversibly inactivates TMZ. Regulation expression research regarding will help rationalize clinical use In this review, we provide overview recent advances field, with particular emphasis on structure, function, regulation, association between
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