Post-transcriptional regulation of O 6 -methylguanine-DNA methyltransferase MGMT in glioblastomas
作者： Valya Ramakrishnan , Deepa Kushwaha , Debbie C. Koay , Hasini Reddy , Ying Mao
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摘要: … Arguably, the most important observation in this study is that tumors and cell lines harboring comparable levels of MGMT mRNA can have widely differing MGMT protein levels. In this …
medra.org 参考文章(29)
Sankar Mitra, Bernd Kaina, Regulation of Repair of Alkylation Damage in Mammalian Genomes Progress in Nucleic Acid Research and Molecular Biology. ,vol. 44, pp. 109- 142 ,(1993) , 10.1016/S0079-6603(08)60218-4
Saadi Ghatan, Douglas D. Kolstoe, John R. Silber, Mitchel S. Berger, Michael S. Bobola, A. Blank, O6-Methylguanine-DNA Methyltransferase Activity in Adult Gliomas: Relation to Patient and Tumor Characteristics Cancer Research. ,vol. 58, pp. 1068- 1073 ,(1998)
Gabriel Iacob, Eduard B Dinca, Current data and strategy in glioblastoma multiforme Journal of medicine and life. ,vol. 2, pp. 386- 393 ,(2009)
B. Demple, B. Sedgwick, P. Robins, N. Totty, M. D. Waterfield, T. Lindahl, Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 2688- 2692 ,(1985) , 10.1073/PNAS.82.9.2688
Jason T. Huse, Heidi S. Phillips, Cameron W. Brennan, Molecular subclassification of diffuse gliomas: seeing order in the chaos. Glia. ,vol. 59, pp. 1190- 1199 ,(2011) , 10.1002/GLIA.21165
Fumiharu Ohka, Atsushi Natsume, Kazuya Motomura, Yugo Kishida, Yutaka Kondo, Tatsuya Abe, Yoko Nakasu, Hiroki Namba, Kenji Wakai, Takashi Fukui, Hiroyuki Momota, Kenichiro Iwami, Sayano Kinjo, Maki Ito, Masazumi Fujii, Toshihiko Wakabayashi, The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma. PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0023332
Anthony E Pegg, Repair of O6-alkylguanine by alkyltransferases Mutation Research-reviews in Mutation Research. ,vol. 462, pp. 83- 100 ,(2000) , 10.1016/S1383-5742(00)00017-X
Yaël Mamane, Emmanuel Petroulakis, Liwei Rong, Kaori Yoshida, Lian Wee Ler, Nahum Sonenberg, eIF4E – from translation to transformation Oncogene. ,vol. 23, pp. 3172- 3179 ,(2004) , 10.1038/SJ.ONC.1207549
Michael Weller, Roger Stupp, Guido Reifenberger, Alba A. Brandes, Martin J. van den Bent, Wolfgang Wick, Monika E. Hegi, MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nature Reviews Neurology. ,vol. 6, pp. 39- 51 ,(2010) , 10.1038/NRNEUROL.2009.197
Fausto J. Rodriguez, Stephen N. Thibodeau, Robert B. Jenkins, Karen V. Schowalter, Bolette L. Caron, Brian P. OʼNeill, Charles David James, Sandra Passe, Jeff Slezak, Caterina Giannini, MGMT immunohistochemical expression and promoter methylation in human glioblastoma Applied Immunohistochemistry & Molecular Morphology. ,vol. 16, pp. 59- 65 ,(2007) , 10.1097/PAI.0B013E31802FAC2F