Extracellular RNAs: development as biomarkers of human disease

作者: Joseph F. Quinn , Tushar Patel , David Wong , Saumya Das , Jane E. Freedman

DOI: 10.3402/JEV.V4.27495

关键词: Cerebrospinal fluidExtracellularMedicineMultiple sclerosisDiseaseKidney diseaseImmunologyHuman diseaseBioinformaticsExtracellular RNACancer

摘要: Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by NIH Common Fund Extracellular RNA Communication Program, examine diverse body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic gastric cancer, cardiovascular disease, chronic kidney neurodegenerative brain tumours, intracranial haemorrhage, multiple sclerosis placental disorders. Progress date plans for future outlined.

参考文章(81)
Chaim Putterman, Iddo Ben-Dov, Olivier Loudig, Beatrice Goilav, Irene Blanco, Dawn Wahezi, Deep-sequencing reveals WHO class-specific urinary microRNAs in human lupus nephritis (P3245) Journal of Immunology. ,vol. 190, ,(2013)
Valya Ramakrishnan, Deepa Kushwaha, Debbie C. Koay, Hasini Reddy, Ying Mao, Liangfu Zhou, Kimberly Ng, Pascal Zinn, Bob Carter, Clark C. Chen, Post-transcriptional regulation of O 6 -methylguanine-DNA methyltransferase MGMT in glioblastomas Cancer Biomarkers. ,vol. 10, pp. 185- 193 ,(2012) , 10.3233/CBM-2012-0245
Emmanuèle Lechapt-Zalcman, Guénaëlle Levallet, Audrey Emmanuelle Dugué, Anne Vital, Marie-Danièle Diebold, Philippe Menei, Philippe Colin, Philippe Peruzzy, Evelyne Emery, Myriam Bernaudin, Françoise Chapon, Jean-Sébastien Guillamo, O6‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation and low MGMT‐encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radiotherapy with concomitant and adjuvant temozolomide Cancer. ,vol. 118, pp. 4545- 4554 ,(2012) , 10.1002/CNCR.27441
Joshua A. Sonnen, Kathleen S. Montine, Joseph F. Quinn, John C.S. Breitner, Thomas J. Montine, Cerebrospinal Fluid Biomarkers in Mild Cognitive Impairment and Dementia Journal of Alzheimer's Disease. ,vol. 19, pp. 301- 309 ,(2010) , 10.3233/JAD-2010-1236
Lin Tan, Jin-Tai Yu, Meng-Shan Tan, Qiu-Yan Liu, Hui-Fu Wang, Wei Zhang, Teng Jiang, Lan Tan, Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. Journal of Alzheimer's Disease. ,vol. 40, pp. 1017- 1027 ,(2014) , 10.3233/JAD-132144
K. Masui, T. F. Cloughesy, P. S. Mischel, Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies. Neuropathology and Applied Neurobiology. ,vol. 38, pp. 271- 291 ,(2012) , 10.1111/J.1365-2990.2011.01238.X
Deepa Kushwaha, Valya Ramakrishnan, Kimberly Ng, Tyler Steed, Thien Nguyen, Diahnn Futalan, Johnny C. Akers, Jann Sarkaria, Tao Jiang, Dipanjan Chowdhury, Bob S. Carter, Clark C. Chen, A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas Oncotarget. ,vol. 5, pp. 4026- 4039 ,(2014) , 10.18632/ONCOTARGET.1974
Nicolas Lellouche, Carlos De Diego, David A Cesario, Marmar Vaseghi, Barbara Natterson Horowitz, Aman Mahajan, Isaac Wiener, Noel G Boyle, Gregg C Fonarow, Kalyanam Shivkumar, None, Usefulness of preimplantation B-type natriuretic peptide level for predicting response to cardiac resynchronization therapy. American Journal of Cardiology. ,vol. 99, pp. 242- 246 ,(2007) , 10.1016/J.AMJCARD.2006.08.018
V. Vuorinen, S. Hinkka, M. Färkkilä, J. Jääskeläinen, Debulking or biopsy of malignant glioma in elderly people - a randomised study. Acta Neurochirurgica. ,vol. 145, pp. 5- 10 ,(2003) , 10.1007/S00701-002-1030-6
William E. Butler, Nadia Atai, Bob Carter, Fred Hochberg, Informatic system for a global tissue-fluid biorepository with a graph theory-oriented graphical user interface. Journal of extracellular vesicles. ,vol. 3, pp. 24247- ,(2014) , 10.3402/JEV.V3.24247