In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing

作者: Simone Kreth , Elisabeth Limbeck , Ludwig C. Hinske , Stefanie V. Schütz , Niklas Thon

DOI: 10.1007/S00401-013-1081-1

关键词:

摘要: … -transcriptional regulation of MGMT, which currently impairs the use of this biomarker for treatment … It is not surprising that miR-648 expression has no predictive value on MGMT mRNA …

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