A Brief History of Airway Smooth Muscle’s Role in Airway Hyperresponsiveness

摘要: A link between airway smooth muscle (ASM) and hyperresponsiveness (AHR) in asthma was first postulated the midnineteenth century, suspected has garnered ever increasing interest over years. AHR is characterized by excessive narrowing of airways response to nonspecific stimuli, it ASM that drives this narrowing. The stimuli can be used demonstrate vary widely, as do potential mechanisms which phenotypic changes or nonmuscle factors contribute AHR. In paper, we review history research on muscle’s role hyperresponsiveness. This ranged from analyzing quantity testing for alterations plastic behavior muscle, distinguishes skeletal cardiac muscles. long continued topic mean precise responsiveness remains elusive, makes a pertinent collection articles.