4.416 – Growth Factors and Protein-Modified Surfaces and Interfaces

摘要: Designing biomaterials that specifically regulate cell behaviors is significant to biomedical device performance. Many functions of cells are regulated by three interactions, namely, with (1) extracellular matrices (ECMs), (2) neighboring cells, and (3) soluble biosignals such as growth factors. Biomaterial researchers have immobilized ECM, adhesion factors, factors the functions. Here, biosignaling reviewed biomaterial designs using mechanisms discussed. First, proteins employed for surface modification summarized. For adhesion, protein, peptides explained. Growth factor enhancement exemplified their action reviewed. The importance these also Second, protein-immobilized surfaces, immobilization biomimetic peptides, molecules corresponding cell–cell Finally, design protein discussed summary future directions.