Design and synthesis of binding growth factors.

摘要: Growth factors play important roles in tissue regeneration. However, because of their instability and diffusible nature, improvements performance would be desirable for therapeutic applications. Conferring binding affinities one way to improve applicability. Here we review techniques conjugating growth polypeptides with particular affinities. Conjugation has been designed at the level gene fusion polypeptide ligation. We summarize discuss designs applications prepared by such conjugation approaches.