Differential effect of formoterol on adenosine monophosphate and histamine reactivity in asthma
作者： JULIA A. NIGHTINGALE , DUNCAN F. ROGERS , PETER J. BARNES
DOI: 10.1164/AJRCCM.159.6.9809090
关键词: Endocrinology 、 Methacholine 、 Bronchoconstriction 、 Formoterol 、 In vivo 、 Histamine 、 Internal medicine 、 Adenosine 、 Asthma 、 Adenosine monophosphate 、 Medicine
摘要: Short-acting β2-agonists provide greater protection against bronchoconstriction induced by adenosine 5 ′ -monophosphate (AMP) than direct-acting bronchoconstrictors such as histamine and methacholine. AMP is thought to cause via release of mediators from mast cells, which suggests that these drugs stabilize cells in vivo. This vivo property has not yet been demonstrated for long-acting β2-agonists. We undertook a double-blind, randomized, placebo-controlled, cross-over study investigate the effects single dose formoterol inhaled Turbuhaler (12 μ g) albuterol (200 on airway responsiveness 16 subjects with mild atopic asthma. Albuterol reduced 4.1 ± 0.5 3.5 0.4 doubling doses, respectively. In contrast, caused protective effect challenge, decreasing 6.0 0.8 4.2 ...
sci-hub.se 参考文章(22)
Peter H Howarth, Stephen R Durham, Tak H Lee, A Barry Kay, Martin K Church, Stephen T Holgate, None, Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma The American review of respiratory disease. ,vol. 132, pp. 986- 992 ,(2015) , 10.1164/ARRD.1985.132.5.986
Paul Rafferty, Richard Beasley, Stephen T. Holgate, The Contribution of Histamine to Immediate Bronchoconstriction Provoked by Inhaled Allergen and Adenosine 5′ Monophosphate in Atopic Asthma The American review of respiratory disease. ,vol. 136, pp. 369- 373 ,(1987) , 10.1164/AJRCCM/136.2.369
Christopher J. Vardey, Anthony T. Nials, Douglas I. Ball, Peter R. Butchers, Robert A. Coleman, Alison A. Humbles, Malcolm Johnson, Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol European Journal of Pharmacology. ,vol. 251, pp. 127- 135 ,(1994) , 10.1016/0014-2999(94)90392-1
Martin K. Church, Jun Hiroi, Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. British Journal of Pharmacology. ,vol. 90, pp. 421- 429 ,(1987) , 10.1111/J.1476-5381.1987.TB08972.X
L-G. Carlsson, E. Arweström, K. Friberg, A. Källén, H. Lunde, C.-G. Löfdahl, Efficacy of cumulative doses of salbutamol administered via Turbuhaler or Diskhaler in patients with reversible airway obstruction Allergy. ,vol. 53, pp. 712- 715 ,(1998) , 10.1111/J.1398-9995.1998.TB03959.X
H.Y.A. Lau, P.L.E. Wong, C.K.W. Lai, J.K.S. Ho, Effects of long-acting β2-adrenoceptor agonists on mast cells of rat, guinea pig, and human International Archives of Allergy and Immunology. ,vol. 105, pp. 177- 180 ,(1994) , 10.1159/000236821
M PALMQVIST, B BALDER, O LOWHAGEN, B MELANDER, N SVEDMYR, L WAHLANDER, Late asthmatic reaction decreased after pretreatment with salbutamol and formoterol, a new long-acting β2-agonist The Journal of Allergy and Clinical Immunology. ,vol. 89, pp. 844- 849 ,(1992) , 10.1016/0091-6749(92)90440-D
R RUFFIN, J FITZGERALD, A REBUCK, A Comparison of the Bronchodilator Activity of Sch 1000 and Salbutamol The Journal of Allergy and Clinical Immunology. ,vol. 59, pp. 136- 141 ,(1977) , 10.1016/0091-6749(77)90215-9
M CUSHLEY, S HOLGATE, Adenosine-induced bronchoconstriction in asthma: Role of mast cell-mediator release The Journal of Allergy and Clinical Immunology. ,vol. 75, pp. 272- 278 ,(1985) , 10.1016/0091-6749(85)90057-0
DAVID A. TAYLOR, MARIANNE W. JENSEN, SARAH L. AIKMAN, JEANETTE G. HARRIS, PETER J. BARNES, BRIAN J. O'CONNOR, Comparison of Salmeterol and Albuterol-induced Bronchoprotection Against Adenosine Monophosphate and Histamine in Mild Asthma American Journal of Respiratory and Critical Care Medicine. ,vol. 156, pp. 1731- 1737 ,(1997) , 10.1164/AJRCCM.156.6.9703047