Adenosine-induced bronchoconstriction in asthma: Role of mast cell-mediator release

摘要: Abstract Adenosine, when it is administered by inhalation to asthmatic subjects, a potent bronchoconstrictor, although its mechanism of action not known. Since adenosine has been demonstrated potentiate IgE-dependent mediator release from mast cells, we have investigated the possible relationship between adenosine-induced bronchoconstriction and cell mediators in 14 subjects. In first study effect putative cell-stabilizing drug cromolyn sodium (SCG) was observed on dose-related changes SG aw FEV 1 produced inhaled histamine seven Inhaled SCG (20 mg) had no airway responses histamine. contrast significantly protected against four subjects as reflected decrease response highest concentrations adenosine, 65 ± 8% 12 3% (mean SEM) for 31 7% 8 FEV,. Those three whose unaffected received regular until hr before studies. separate eight single causing maximum 61 4% fall at 10 min, significant circulating levels histamine, neutrophil chemotactic factor, or cyclic AMP. Together these two studies suggest that consequence enhanced cell-mediator inhibitory effects occur other than through stabilization.