Cold stress-induced neuroinvasiveness of attenuated arboviruses is not solely mediated by corticosterone.

摘要: In previous studies we have shown that various stress paradigms can induce the penetration of noninvasive, attenuated viruses into central nervous system (CNS). Since glucocorticoids levels are elevated during stress, compared effect cold and corticosterone (CS) injection on neuroinvasiveness a non-invasive encephalitic virus, WN-25 (West Nile). Exposure inoculated mice to or CS resulted in high viremia marked increase mortality when control untreated mice. treatment led blood virus as nontreated (3.2 3.1 vs.>1 log 10 PFU/ml). Cold (5 000 ng/mouse) caused rate 70% 50% respectively. No was recorded groups (p<0.05). Passive transfer serum from uninfected stressed nonstressed mice, similar mortality. The passive transferred animals 500 ng/ml, only 2% (100 vs. 5 ng) dose required obtain viral injected directly. Therefore, concluded not sole factor responsible for infection outcome.