Different chemokine expression in lethal and non-lethal murine west nile virus infection
作者： Kazuya Shirato , Takashi Kimura , Tetsuya Mizutani , Hiroaki Kariwa , Ikuo Takashima
DOI: 10.1002/JMV.20205
关键词:
摘要: West Nile (WN) virus is a mosquito-borne flavivirus that can cause lethal encephalitis in humans and horses. The WN endemic New York City (NY) 1999 caused large-scale mortality of wild birds was not evident areas other parts the world, pathogenesis strain isolated NY (NY strain) appears to differ from previously strains. However, infection remains unclear. This study examined CC (RANTES/CCL5, MIP-1 alpha/CCL3, beta/CCL4) CXC (IP-10/CXCL10, B lymphocyte chemoattractant (BLC/CXCL13), cell- monocyte-activating chemokine (BMAC/CXCL14)) expression during non-lethal Eg101 mice. We found mRNA chemokines, RANTES, alpha, beta, IP-10 highly up-regulated brain strain-infected By contrast, BLC detected either group mice, BMAC late stage with relative levels
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