Low maternal circulating levels of vitamin D as potential determinant in the development of gestational diabetes mellitus.

摘要: Gestational diabetes mellitus (GDM), defined as any glucose intolerance with the onset or first recognition during pregnancy, is characterized by rising incidence, fostered worldwide increase of pathological nutritional status from young age. Clinical research has intended to identify potential risk factors, suggested improvements in screening strategies, and recommended combination between promotion an appropriate lifestyle before pregnancy selected therapeutic approaches. Preventing hyperglycemia could have several benefits, ranging clinical side (reduction adverse perinatal long-term sequelae) financial (cost reduction healthcare systems). Among factors recognized, deficiency 25-hydroxyvitamin D [25(OH)D], already acknowledged involved calcium homeostasis, pathogenesis cardiovascular, oncological, infective immunity diseases, predispose development both type 1 2 diabetes, modifying activity pancreatic β-cells vitamin (VD) receptor. In pregnant women, lower 25(OH)D concentrations been present inverse association maternal glycaemia, insulin resistance, increased GDM. spite growing body evidence, there not full agreement on GDM based VD supplementation. attempt bring up-to-date role low levels subsequent GDM, this narrative review, medium-high-quality randomized trials, systematic reviews, meta-analysis published last decade, a twofold purpose: firstly, elucidate relationship GDM; secondly, illuminate impact supplementation onset.