Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

摘要: Objective To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables. Design Systematic review meta-analysis randomized controlled trials (RCTs). Setting Not applicable. Patient(s) Pregnant women neonates. Intervention(s) PubMed 5 other research databases were searched through March 2014 for RCTs evaluating ± calcium/vitamins/ferrous sulfate vs. a control (placebo or active) pregnancy. Main Outcome Measure(s) Measures were: circulating 25-hydroxyvitamin [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small age (SGA), low weight, preterm birth, length, cesarean section. Mantel-Haenszel fixed-effects models used, owing to expected scarcity outcomes. Effects reported as relative risks their 95% confidence intervals (CIs). Result(s) Thirteen (n = 2,299) selected. Circulating 25(OH)D levels significantly higher at term, compared with group (mean difference: 66.5 nmol/L, CI 66.2–66.7). Birth weight length greater neonates in group; mean 107.6 g (95% 59.9–155.3 g) 0.3 cm 0.10–0.41 cm), respectively. Incidence GDM, SGA, section not influenced by supplementation. Across RCTs, doses types supplements, first administration, heterogeneous. Conclusion(s) Vitamin was associated increased maternal neonatal Larger, better-designed clinically relevant are necessary reach definitive conclusion.