Components characterization of total tetraploid jiaogulan ( Gynostemma pentaphyllum ) saponin and its cholesterol-lowering properties
作者： Jie Liu , Yanfang Li , Haiming Shi , Thomas Wang , Xianli Wu
DOI: 10.1016/J.JFF.2016.03.013
关键词: Bile acid 、 Cholesterol 7 alpha-hydroxylase 、 Cholesterol uptake 、 Internal medicine 、 Gynostemma pentaphyllum 、 Endocrinology 、 ABCG5 、 Biochemistry 、 Saponin 、 Chemical structure 、 Metabolism 、 Chemistry 、 Food science 、 Nutrition and Dietetics 、 Medicine (miscellaneous)
摘要: Abstract This study characterized chemical structures of tetraploid jiaogulan saponins, and investigated their cholesterol-lowering effects mechanisms in hamsters fed a high-fat diet (HFD). Nine including five reported for the first time, were obtained from total saponins (TJS) elucidated according to 2D NMR HR-MS data. Administration TJS effectively decreased plasma cholesterol by 17.4% 32.6%, triacylglycerols 22.8% 47.7% LDL-C 22.0% 40.2%, respectively. Moreover, supplementation with significantly increased faecal excretion bile acids 43.8% 64.4%, up-regulated intestinal mRNA levels ABCG5/8, LXRα, hepatic CYP7A1 ABCG5 on HFD. In addition, micelle solubility suppressed uptake cultured Caco-2 cells. Taking together, may reduce increasing through modulation genes involved absorption metabolism.
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