Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation

摘要: Abstract Objectives: Glucosamine and chondroitin supplements have been shown to anti-inflammatory properties in both vitro studies animal models; however, little is known about these relationships humans. The VITamins Lifestyle (VITAL) biomarker study evaluated the associations between use of a panel circulating inflammatory biomarkers. Design: Study participants included 217 men women age 50–75 years living Seattle metropolitan area. Use glucosamine was ascertained by home interview/supplement inventory. Inflammation assessed using blood urine collected at time interview. Measures systemic inflammation plasma high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, soluble TNF receptors I II, urinary prostaglandin E2-metabolite (PGE-M). Multivariate-adjusted linear regression used evaluate suppl...