Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort.

作者: Elizabeth D. Kantor , Christina C. Newton , Edward L. Giovannucci , Marjorie L. McCullough , Peter T. Campbell

DOI: 10.1007/S10552-018-1003-6

关键词: Colorectal cancerHematologyPublic healthLower riskMedicineCohortEpidemiologyGlucosamineInternal medicineCancer prevention

摘要: Use of glucosamine supplements has been associated with reduced risk colorectal cancer (CRC) in previous studies; however, information on this association remains limited. We examined the between use and CRC among 113,067 men women Cancer Prevention Study II Nutrition Cohort. Glucosamine was first reported 2001 updated every 2 years thereafter. Participants were followed from through June 2011, during which time 1440 cases occurred. As observed prior studies, current glucosamine, modeled using a time-varying exposure, lower (HR 0.83; 95% CI 0.71–0.97) compared to never use. However, for reasons that are unclear, reduction shorter-duration 0.68; 0.52–0.87 users ≤ 2 years use) rather than longer-duration 0.90; 0.72–1.13 3 < 6 years use; HR 0.99; 0.76–1.29 ≥ 6 years use). Further research is needed better understand CRC, how may vary by duration

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