The detection of alpha 1-fetoprotein in patients with viral hepatitis.

作者: H. K. B. Silver , J. Deneault , P. Gold , J. Shuster , W. G. Thompson

DOI:

关键词: Hepatitis BBlood proteinsBiologyInternal medicineHepatitisRadioimmunoassayImmunologyAntigenTransaminaseGastroenterologyViral hepatitisAlpha-fetoprotein

摘要: Alpha fetoprotein (AFP) was detected in sera (351 samples) of 128 patients with viral hepatitis by radioimmunoassay. 77 positive tests for AFP were obtained. These results demonstrated on 1 or more samples taken from 40 (31%) the studied; highest value obtained 4400 ng/ml. Hepatitis B antigen (HBAg) 26/40 (65%) whom during disease process. However 58/88 (66%) who seronegative also HBAg their sera. Chi-square analysis revealed no significant difference occurrence detectable between seropositive and patients. Individuals had statistically different concentration protein than HBAg. 24 tested serially over a 2-week period. Both peak glutamic-pyruvic transaminase (GPT) total bilirubin levels higher range those 10/24 (P < .001) 14/24 seronegative. Appearance related to severity liver tissue destruction as reflected serum GPT. attained 5-16 days after GPT appeared circulation.

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