Persistent suppression of resting energy expenditure after acute hypoxia.

摘要: Resting energy expenditure (REE) is known to be influenced by various ambient conditions such as oxygen supply. Investigations in healthy subjects during acute hypoxia revealed a drop REE, but persistent effects after had ended have not been examined so far. Although indirect calorimetry well-established method measure it may lead false conclusions when hyperventilation, rise lactate or catecholamines, and decrease of food intake accompany hypoxia. Therefore, we determined REE men under controlled supply glucose clamp. In double-blind crossover study design, induced for 30 minutes decreasing saturation 75% (vs 96% control session) 13 men. Indirect was performed at baseline 150 ended. Plasma held stable between 4.5 5.5 mmol/L, well catecholamine concentrations were monitored. parallel, measured alterations hormones the hypothalamic-pituitary-thyroid axis, which one factor mediating changes REE. decreased (from 1656+/-80 1564+/-97 kcal/d) compared with normoxic condition (1700+/-82 1749+/-79 kcal/d, P=.037), whereas respiratory quotient remained (P=.79). lactate, levels, pituitary thyroid secretory activity unchanged (P>.2). Our data demonstrate that persists hypoxia, indicating an adaptation metabolism. This should valued additive pathogenic diseases disturbed