Endocrine Changes in a Rat Model of Chronic Hypoxia Mimicking Cyanotic Heart Disease
作者： Dany Zayour , Sami T. Azar , Nabil Azar , Michel Nasser , Mounir Obeid
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摘要: Objective. The endocrine system plays an important role in the adaptation to hypoxia. The aim of this study is assess effect chronic hypoxia on changes a neonatal animal model mimicking cyanotic heart disease. Methods. Sprague–Dawley rats were placed normobaric hypoxic environment at birth and oxygen levels maintained 10% airtight Plexiglas chamber. Controls remained room air. Animals sacrificed 4 8 weeks life. Hematocrit, Free T4 (FT4), Thyrotropin (TSH), corticosterone, Growth hormone (GH) measured. Results. Significant polycythemia developed rats. significantly lower (H) group compared control (C) with FT4 2.44 ± 1.11 ng/dL 4.35 1.62 p value <0.005 2.01 0.36 3.25 0.54 < 0.01. At TSH (1.84 0.9 ng/mL vs. 3.1...
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