The Contribution of National Spontaneous Reporting Systems to Detect Signals of Torsadogenicity: Issues Emerging from the ARITMO Project
作者： Emanuel Raschi , Elisabetta Poluzzi , Francesco Salvo , Ariola Koci , Marc Suling
DOI: 10.1007/S40264-015-0353-1
关键词: Spontaneous reporting 、 Pharmacology toxicology 、 Rare events 、 Data science 、 Medicine
摘要: Introduction Spontaneous reporting systems (SRSs) are pivotal for signal detection, especially rare events with a high drug-attributable component, such as torsade de pointes (TdP). Use of different national SRSs is rarely attempted because inherent difficulties, but should be considered on the assumption that diluted in international databases.
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