Cardiovascular safety of antipsychotics: a clinical overview.
作者： Christoffer Polcwiartek , Kristian Kragholm , Ole Schjerning , Claus Graff , Jimmi Nielsen
DOI: 10.1517/14740338.2016.1161021
关键词: Sudden cardiac death 、 Ecg monitoring 、 Intensive care medicine 、 Torsades de pointes 、 In patient 、 Corrected qt 、 Adverse effect 、 Cardiovascular safety 、 Medicine 、 Antipsychotic treatment 、 Pharmacology
摘要: ABSTRACTIntroduction: Although antipsychotics have been associated with sudden cardiac death (SCD), they still remain a cornerstone in the treatment of psychiatric patients. Most an unfavorable cardiovascular adverse effect profile, and SCD may occur even patients no risk factors.Areas covered: This clinical overview summarizes safety by focusing on wide range effects. In addition, we also discuss current guidelines regarding routine electrocardiogram (ECG) monitoring.Expert opinion: As is multifactorial, contribution from antipsychotic remains largely unknown. Cardiovascular effects vary substantially, when used therapeutic doses. Currently, most concern focuses antipsychotic-induced corrected QT prolongation, as this increase Torsades de Pointes eventually SCD. However, other serious cardiovascula...
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