Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion☆

摘要: Non-covalent binding of polymers to a mucin/epithelial surface has been demonstrated for variety on biological surfaces. Structural features the polymer which are important bioadhesion have explored using copolymer acrylic and methacrylic acid with variation in charge density hydrophobicity molecules. Both calculated determined experimentally both were related mucosal fresh rabbit stomach. The more parameter is density. In addition structural adhesive polymer, physical aspects such as degree rate hydration well particle size bioadhesion, especially an vivo situation. Rates by labor intensive microscopic technique, function pH size. Lastly, intrinsic series insoluble carboxylic determined. An estimated cohesive strength stomach glycoprotein was obtained from kinetic studies.