Optimization of the Conditions for Copper‐Mediated N‐Arylation of Heteroarylamines
作者： Yifeng Liu , Yajun Bai , Juan Zhang , Yangyang Li , Junping Jiao
关键词: Copper 、 Catalysis 、 Chemistry 、 Coupling reaction 、 Aryl 、 Nucleophile 、 Ligand 、 Organic chemistry 、 Solvent 、 Polymer chemistry 、 Base (chemistry)
摘要: Simple and inexpensive copper-mediated N-arylation ofheteroarylamines was achieved by using N,N′-dimethylethylenediamine as a ligand K2CO3 base in dioxane heated at 100 °C. In this coupling reaction, the influence of copper species, ligand, solvent investigated detail. N-Arylated derivatives several heteroarylamines were synthesized under optimized reaction conditions, all products isolated good yields. By controlling amount CuI/DMEDA added, with weak nucleophilic activity coupled aryl iodides or bromides. The catalyst for C–N bond-forming follows order CuI > Cu0 > CuII. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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