作者: Ruel N. Wright , Sidney Levitsky , Charles Holland , Harold Feinberg
DOI: 10.1016/0022-4804(78)90175-0
关键词: Creatine 、 Perfusion 、 Balloon 、 Ischemia 、 Contractility 、 Anesthesia 、 Cardiology 、 Air embolism 、 Cardiopulmonary bypass 、 Internal medicine 、 Potassium 、 Medicine 、 Surgery
摘要: Abstract Aortic cross-clamping is an essential adjunct to a variety of cardiac surgical procedures requiring quiet flaccid heart and avoidance systemic air embolism. The consequences excluding the from perfusion, oxygen, substrate are time dependent lead ultimately irreversible damage myocardium. goal complete preservation myocardial function metabolism during ischemia has not been realized even with best clinically applicable techniques. present study was designed evaluate effects sequential aortic interrupted by reperfusion similar that used in clinical practice. advantages induced arrest potassium chloride solution at onset were assessed second group animals. A total 27 mongrel dogs supported normothermic cardiopulmonary bypass subjected four cross-clamp periods 5-min reper-fusion periods. included evaluation left ventricular performance using isovolumic balloon technique assessment “stop-freeze” biopsies biochemical assay for ATP, ADP, AMP, creatine phosphate. data demonstrate repeated induction ischemic results profound depletion adenine nucleo-tides severe depression contractility. Using potassium-induced arrest, normal contractile preserved along conservation nucleo-tides, suggesting normothermia, can be achieved.