Comprehensive identification of mutational cancer driver genes across 12 tumor types

作者: David Tamborero , Abel Gonzalez-Perez , Christian Perez-Llamas , Jordi Deu-Pons , Cyriac Kandoth

DOI: 10.1038/SREP02650

关键词: DNA Mutational AnalysisCarcinogenesisGeneticsDiseaseCancerGenomeBiologyExome sequencingGene regulatory networkGenomics

摘要: … genes. We provide a list of 291 high-confidence cancer driver genes acting on 3,205 tumors from 12 different cancer types. Among those …

参考文章(49)
Anna, C. Schinzel, Oncogenic transformation and experimental models of human cancer Frontiers in Bioscience. ,vol. 13, pp. 71- 84 ,(2008) , 10.2741/2661
Takehiko Sasaki, Junko Irie-Sasaki, Yasuo Horie, Kurt Bachmaier, Jimmie E. Fata, Martin Li, Akira Suzuki, Dennis Bouchard, Alexandra Ho, Mark Redston, Steven Gallinger, Rama Khokha, Tak W. Mak, Phillip T. Hawkins, Len Stephens, Stephen W. Scherer, Ming Tsao, Josef M. Penninger, Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ Nature. ,vol. 406, pp. 897- 902 ,(2000) , 10.1038/35022585
Yusuke Imamura, Shinichi Sakamoto, Takumi Endo, Takanobu Utsumi, Miki Fuse, Takahito Suyama, Koji Kawamura, Takashi Imamoto, Kojiro Yano, Katsuhiro Uzawa, Naoki Nihei, Hiroyoshi Suzuki, Atsushi Mizokami, Takeshi Ueda, Naohiko Seki, Hideki Tanzawa, Tomohiko Ichikawa, FOXA1 Promotes Tumor Progression in Prostate Cancer via the Insulin-Like Growth Factor Binding Protein 3 Pathway PLoS ONE. ,vol. 7, pp. e42456- ,(2012) , 10.1371/JOURNAL.PONE.0042456
Jüri Reimand, Omar Wagih, Gary D. Bader, The mutational landscape of phosphorylation signaling in cancer Scientific Reports. ,vol. 3, pp. 2651- 2651 ,(2013) , 10.1038/SREP02651
Jüri Reimand, Gary D Bader, Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers Molecular Systems Biology. ,vol. 9, pp. 637- 637 ,(2013) , 10.1038/MSB.2012.68
E. Premkumar Reddy, Roberta K. Reynolds, Eugenio Santos, Mariano Barbacid, A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene Nature. ,vol. 300, pp. 149- 152 ,(1982) , 10.1038/300149A0
David Tamborero, Nuria Lopez-Bigas, Abel Gonzalez-Perez, Oncodrive-CIS: A Method to Reveal Likely Driver Genes Based on the Impact of Their Copy Number Changes on Expression PLoS ONE. ,vol. 8, pp. e55489- ,(2013) , 10.1371/JOURNAL.PONE.0055489
Jinhwa Lee, Sung Soo Kim, The function of p27 KIP1 during tumor development Experimental and Molecular Medicine. ,vol. 41, pp. 765- 771 ,(2009) , 10.3858/EMM.2009.41.11.102
Abel Gonzalez-Perez, Nuria Lopez-Bigas, Abstract LB-401: Functional impact bias reveals cancer drivers Cancer Research. ,vol. 72, ,(2012) , 10.1158/1538-7445.AM2012-LB-401
Michael S Lawrence, Petar Stojanov, Paz Polak, Gregory V Kryukov, Kristian Cibulskis, Andrey Sivachenko, Scott L Carter, Chip Stewart, Craig H Mermel, Steven A Roberts, Adam Kiezun, Peter S Hammerman, Aaron McKenna, Yotam Drier, Lihua Zou, Alex H Ramos, Trevor J Pugh, Nicolas Stransky, Elena Helman, Jaegil Kim, Carrie Sougnez, Lauren Ambrogio, Elizabeth Nickerson, Erica Shefler, Maria L Cortés, Daniel Auclair, Gordon Saksena, Douglas Voet, Michael Noble, Daniel DiCara, Pei Lin, Lee Lichtenstein, David I Heiman, Timothy Fennell, Marcin Imielinski, Bryan Hernandez, Eran Hodis, Sylvan Baca, Austin M Dulak, Jens Lohr, Dan-Avi Landau, Catherine J Wu, Jorge Melendez-Zajgla, Alfredo Hidalgo-Miranda, Amnon Koren, Steven A McCarroll, Jaume Mora, Ryan S Lee, Brian Crompton, Robert Onofrio, Melissa Parkin, Wendy Winckler, Kristin Ardlie, Stacey B Gabriel, Charles WM Roberts, Jaclyn A Biegel, Kimberly Stegmaier, Adam J Bass, Levi A Garraway, Matthew Meyerson, Todd R Golub, Dmitry A Gordenin, Shamil Sunyaev, Eric S Lander, Gad Getz, None, Mutational heterogeneity in cancer and the search for new cancer-associated genes Nature. ,vol. 499, pp. 214- 218 ,(2013) , 10.1038/NATURE12213